Interleukin 28B Gene Polymorphism and Association with Chronic Hepatitis C Therapy Results in Latvia
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چکیده
منابع مشابه
Interleukin 28B Gene Polymorphism and Association with Chronic Hepatitis C Therapy Results in Latvia
Introduction. With the standard treatment of chronic hepatitis C, sustained virological response (SVR) can be achieved only in half of all patients. Interleukin-28B appears to be involved in the control of HCV infection, and the genetic polymorphism of the encoding IL-28B gene may determine the efficacy of clearance of HCV. The aim of this paper was to detect IL-28B gene polymorphism in Latvia ...
متن کاملAssociation of Hepatitis C Virus Infection and Interleukin-28B Gene Polymorphism in Chinese Children
OBJECTIVE To preliminarily explore the association of rs12979860 and rs8099917 SNPs with chronic HCV infection in Chinese Han children. METHODS Chronic HCV infection patients (n=277; 1-17 years old, 4.5 years old in average) and healthy subjects (n=150, children; 2-17 years old, 5.2 years old in average) were recruited and tested by PCR combining direct sequencing. The differences between the...
متن کاملAssociation of interleukin-28B genotype and hepatocellular carcinoma recurrence in patients with chronic hepatitis C.
PURPOSE Several single-nucleotide polymorphisms (SNP) in the interleukin-28B (IL-28B) locus have recently been shown to be associated with antiviral treatment efficacy for chronic hepatitis C (CHC). However, such an association with hepatocellular carcinoma (HCC) is unkno3 we investigated the association between the IL-28B genotype and the biology and clinical outcome of patients with HCC recei...
متن کاملAssociation of Interleukin 28B genotype and hepatocellular carcinoma recurrence in patients with chronic hepatitis C Authors:
Purpose: Several single nucleotide polymorphisms (SNPs) in the interleukin 28B (IL28B) locus have recently been shown to be associated with antiviral treatment efficacy for chronic hepatitis C (CH-C). However, such an association with hepatocellular carcinoma (HCC) is unknown. Here, we investigated the association between the IL28B genotype and the biology and clinical outcome of HCC patients r...
متن کاملCharacterization of the Interleukin-28B Gene rs12979860 C/T Polymorphism in Turkish Chronic Hepatitis C Patients and Healthy Individuals.
BACKGROUND Host genetic factors can affect the progress of hepatitis-C virus (HCV) infection. Interleukin-28B (IL28B) single nucleotide polymorphisms may play an important role in the clearance of HCV spontaneously or with treatment. AIMS The aim of our study was to evaluate the rate of IL28B genotypes in patients with Chronic Hepatitis-C (CHC) and healthy control subjects and to examine the ...
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ژورنال
عنوان ژورنال: Hepatitis Research and Treatment
سال: 2012
ISSN: 2090-1364,2090-1372
DOI: 10.1155/2012/324090